It shall be noticed, that in men, approximately 5% of testosterone undergoes 5α-reduction to form the more potent androgen, dihydrotestosterone (DHT), also known as androstanolone. From another side approximately % of testosterone is converted into estradiol (the primary female sex hormone) by aromatase an enzyme expressed in the brain, liver, and adipose tissues. Hence, don`t forget to take precautions to avoid respective side effects. Thereof we recommend to perform blood works and take aromatase inhibitors on cycle (if required, anastrozole preferably) and SERMs (clomifene, toremifene) during post cycle therapy (PCT).
Short-term side effects include insomnia, high blood pressure, night sweats, and decreased libido. However, since women will suffer virilization effects even at small doses, this drug should not be taken by a female. Kidney toxicity has been suggested, but has not yet been proven, and scientific evidence supporting the idea is absent from the bodybuilding community that perpetuates this idea. The origin of this myth most likely has to do with the rust colored oxidized metabolites of trenbolone which are excreted in urine and often mistaken for blood. Trenbolone and 17epi-trenbolone are both excreted in urine as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that trenbolone leaves the body as beta-glucuronides or sulfates.