A lot of bodybuilders consider this drug to be the strongest oral that there is for sheer mass gain. It is important to note that some of this mass will be from water bloat caused by the steroid. While Anadrol is a DHT derived compound and therefore can’t convert directly to estrogen, it still is known for many estrogenic related side effects. Some have speculated that A-50 somehow triggers the body’s natural estrogen receptors into overdrive. Stronger anti-estrogens such as Letrozole and Exemestane have been shown to greatly suppress the body’s estrogen levels and can both be very effective in keeping these types of side effects to a minimum while using Oxymetholone.
Oxymetholone is the strongest anabolic steroid known today (in terms of its anabolic effects) but also one of the most dangerous to use. Except perhaps Halotestin (fluoxymesterone), there is little more liver toxic steroid on the market. Anadrol should therefore be used with great caution, if at all. That said, let the muscle mass gains with Anadrol are huge, much easier not to maintain and aesthetically not very attractive. The reason is considerable fat and water retention caused by estrogenic effects of this drug. This is true despite the fact that oxymetholone practically does not aromatize. The likely explanation is that Anadrol itself activates the estrogen receptor, which is not unlikely taking into account the shape of the molecule (having an A-ring similar to that of oestradiol). It is obvious that the accessory anti-estrogen drugs is often used in conjunction with this drug, but it must be remembered that a significant portion of its effects are mediated by the activation of estrogen receptor, meaning that anti- Estrogen can also reduce mass earnings per Anadrol. Safety: Oxymetholone can cause many side effects not experienced when using other steroids. These include nausea, vomiting, diarrhea, insomnia, headache and abdominal pain. Hepatotoxicity of Anadrol is severe and the treatment should not exceed 5 weeks (which does not mean it can not cause liver damage if used for shorter period). Estrogenic side effects include gynecomastia and high blood pressure.