• Herbal Weight Loss Ingredient / Ephedra Substitute / Synephrine / Risks : Since the banning of ephedra-containing weight loss products, products containing C. aurantium have surfaced. C. aurantium contains flavonoids and can increase blood levels of drugs (cyclosporine, felodipine, indinavir) with potential drug interactions and attendant side effects. Some extracts and/ or supplements contain high levels of synephrine which may cause increased heart rate and other signs and symptoms associated with increased metabolism. (See safety studies above) ( 3 )
Extracts and ingredient of weight loss supplements in the cybermarket.
Droxidopa is a prodrug of norepinephrine used to increase the concentrations of these neurotransmitters in the body and brain .  It is metabolized by aromatic L-amino acid decarboxylase (AAAD), also known as DOPA decarboxylase (DDC). Patients with NOH have depleted levels of norepinephrine which leads to decreased blood pressure or hypotension upon orthostatic challenge.  Droxidopa works by increasing the levels of norepinephrine in the peripheral nervous system (PNS), thus enabling the body to maintain blood flow upon and while standing .