Oxedrine uses

Each Capsule Contains:

Hydroxycitrate complex (from Garcinia quaesita/cambogia) 200mg
equiv. hydroxycitric acid 100mg
Standardised herbal extracts equiv. to dry:
Paullinia cupana (Guarana) seed 500mg (providing caffeine)
Coleus forskohlii (Coleus) root 750mg (equiv. Foskolin )
Citrus aurantium (Bitter orange) fruit (equiv. oxedrine 10mg)
Camellia sinensis (green tea) leaf 250mg
Herbal extracts dry: Zingiber officinale (Ginger) rhizome100mg
Capsicum frutescens (cayenne) fruit 50mg
Levocarnitine tartrate Chromium (as picolinate)15ug Iodine (as potassium iodide) 30ug
Also contains: Encapsulating aids Contains no: Yeast, gluten, dairy, preservatives.

Citrus aurantium (Bitter Orange)

PDE3 inhibitors are a type of phosphodiesterase inhibitors . Inhibition of the PDE isoenzyme 3 leads to an increase of intracellular concentrations of the second messenger cyclic adenosine monophosphate (cAMP). cAMP mediates the phosphorylation of protein kinases , which in turn activates cardiac calcium channels . An increased calcium influx from the sarcoplasmic reticulum (SR) during phase 2 (the plateau phase) of the cardiac action potential leads to a positive inotropic effect of PDE3 inhibitors: they increase the force of cardiac contraction. Increased reflux of calcium into the SR following the plateau phase is responsible for their positive lusitropic effect: they increase relaxation speed. Additionally, PDE3 inhibitors act as vasodilators . [1] [2]

Dobutamine is predominantly a β 1 -adrenergic agonist , with weak β 2 activity, and α 1 selective activity, although it is used clinically in cases of cardiogenic shock for its β 1 inotropic effect in increasing heart contractility and cardiac output. Dobutamine is administered as a racemic mixture consisting of both (+) and (−) isomers ; the (+) isomer is a potent β 1 agonist and α 1 antagonist, while the (−) isomer is an α 1 agonist. [4] The administration of the racemate results in the overall β 1 agonism responsible for its activity. (+)-Dobutamine also has mild β 2 agonist activity, which makes it useful as a vasodilator. [5]

Oxedrine uses

oxedrine uses

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