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- One of the most common hypersensitivity disorder in dogs and cats
- Onset at any age with multiple mechanisms for mediation - not always totally IgE-mediated.  When it is IgE mediated, the hypersensitivity is measurable by in vitro tests.  Flea hypersensitivity is sometimes cell-mediated with delayed reaction - up to 10 days post exposure.  Negative in vitro test probably indicate cell-mediated basis and other mechanisms not quite understood.  There is no substitute for complete flea control!

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